Last season's Premier Division champions, Stapleford Town, sit on top of the Samba Nottinghamshire Senior League, supported by Euro Soccer Company, with two wins from two. They travel to the Memorial Ground to face Southwell City in a rematch of the 2019 Senior Cup final. Southwell were the winners that day and will be looking to repeat the feat.
A host of other teams will be hoping to make it two wins from two matches, including the two promoted sides, Burton Joyce and Woodthorpe Park Rangers. BJ welcome Eastwood CFC Development to The Poplars while Woodthorpe travel to Spa Lane to take on Aslockton & Orston.
Last season's runners up, Bingham Town, suffered a heavy defeat on opening day, they will attempt to bounce back as they visit the Ron Steel Sports Ground to face AFC Dunkirk.
Awsworth Villa have endured a torrid start to the campaign but will hope for an upturn in fortunes when they meet FC Cavaliers at the Forest Sports Zone. Bilborough Town will also be looking to pick up their first point as they host Wollaton at the Harvey Hadden Stadium.
Calverton Miners Welfare entertain Attenborough at Hollinwood Lane and Magdala Amateurs welcome Cotgrave to Roko.
In Division One, Radcliffe Olympic get their campaign underway with Kirton Brickworks the visitors to Wharf Lane. Newly promoted AFC Top Valley entertain Basford United Community at Eagle Valley.
Radford Reserves travel to Bestwood Miners Welfare and Wollaton Reserves head to the David Ross Sports Village to play Bridgford United. Kimberley Miners Welfare Reserves and Beeston meet at the Stag Ground.
In Division Two, Ravenshead Reds welcome Bingham Town Reserves to Cornwater with a number of their squad missing due to injury or cricket commitments, including club captain Brad Martin. Senir debuts could be given to Tyler Burton and Tom Miller, and Amandeep Basi could make his first competitive appearance for the club.
United Grays make their NSL bow by hosting Clifton All Whites Development at Eagle Valley. Other new boys, Asha and Beeston Old Boys, entertain Stapleford Town Reserves at the MJ Robinson Structures Arena and travel to Woodview to play Cotgrave Reserves respectively.
Elston United welcome Keyworth United Reserves to Balderton Playing Field.